K3125

Kojic acid

≥98.5% (HPLC), powder, tyrosinase inhibitor

• Sinonimo/i: 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
• Formula empirica (notazione di Hill): C₆H₆O₄
• Numero CAS: 501-30-4
• Peso molecolare: 142.11
• Beilstein: 120895
• Numero CE: 207-922-4
• Numero MDL: MFCD00006580
• Codice UNSPSC: 12352106
• ID PubChem: 24896226
• NACRES: NA.77

Proprietà

• product name: Kojic acid,
• Saggio: ≥98.5% (HPLC)
• Forma fisica: powder
• Punto di fusione: 152-155 °C (lit.)
• Stringa SMILE: OCC1=CC(=O)C(O)=CO1
• InChI: 1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2; BEJNERDRQOWKJM-UHFFFAOYSA-N

Descrizione

Applicazioni

Kojic acid has been used:

• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
• as a reference inhibitor standard for screening tyrosinase inhibition
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells

Azioni biochim/fisiol

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.

Tyrosinase inhibitor.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)