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Documenti fondamentali

I7389

Interleukin-3 human

Name: Interleukin-3 human
Brand: SIGMA

IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

hIL-3, IL-3

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About This Item

Numero MDL:

MFCD00147276

Codice UNSPSC:

12352202

Prodotti consigliati

Slide 1 of 1

1 of 1

Sigma-Aldrich

I5879

3-isobutil-1-metilxantina

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in E. coli

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

<0.5 ng/mL ED₅₀

Qualità

endotoxin tested

Confezionamento

pkg of 4 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.1 EU/μg

N° accesso UniProt

P08700

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IL3(3562)

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Azioni biochim/fisiol

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Definizione di unità

One unit is the amount of IL-3 required to induce half-maximal incorportion of ³H thymidine. Activity also is expressed in Reference units (NIBSC reference preparation for IL-3 code 88/87).

Stato fisico

Lyophilized from a 0.2 μm filtered solution.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Basophils exhibit antibacterial activity through extracellular trap formation.

S Yousefi et al.

Allergy, 70(9), 1184-1188 (2015-06-05)

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report

Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia.

Hai Zhou et al.

Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)

Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production

Genuine Immunomodulation With dSLIM.

Kerstin Kapp et al.

Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)

Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist

Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity.

Amy H Lin et al.

Journal of virology, 88(17), 10066-10077 (2014-06-27)

We developed a Moloney mouse leukemia virus (MLV)-based retroviral replicating vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and blood in clinical trials. Here, we investigated the interaction between Toca 511 and human host

Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes.

Cristina Ghirelli et al.

Cancer research, 75(14), 2775-2787 (2015-05-16)

Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid predendritic cells (pDC), a cell type critical to anti-viral immunity.

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