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I5657

Anti-Interleukin-22 Receptor, N-Terminal antibody produced in rabbit

Name: Anti-Interleukin-22 Receptor, N-Terminal antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-IL-22R

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About This Item

Numero MDL:

MFCD04040433

Codice UNSPSC:

51111800

NACRES:

NA.41

Origine biologica

rabbit

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen ~62 kDa

Reattività contro le specie

human

Concentrazione

~1 mg/mL

tecniche

ELISA: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

N° accesso UniProt

Q8N6P7

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... IL22RA1(58985)

Immunogeno

synthetic peptide corresponding to amino acids 31-46 of human IL-22 recptor precursor.

Azioni biochim/fisiol

Interleukin-22 (IL-22) belongs to the IL-10 family of T-cell associated cytokines, highly expressed by Th17 cell subset and also by cells of innate immunity system. The cellular effects of IL-22 are mediated by a heterodimeric receptor made up of IL-22 and IL-10Rβ. IL-22 signaling mediates proliferation of epithelial cells during inflammation mainly by the activation of STAT1 and STAT3 signaling.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Codice della classe di stoccaggio

10 - Combustible liquids

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Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.

L Dumoutier et al.

Journal of immunology (Baltimore, Md. : 1950), 164(4), 1814-1819 (2000-02-05)

IL-9 is a Th2 cytokine active on various cell types such as T and B lymphocytes, mast cells, and eosinophils, and potentially involved in allergy and asthma. To understand better the molecular mechanisms underlying the activity of this cytokine, we

IL-22 and inflammation: leukin' through a glass onion.

Lauren A Zenewicz et al.

European journal of immunology, 38(12), 3265-3268 (2008-11-20)

IL-22 is a Th17 T-cell-associated cytokine that is highly expressed during chronic inflammation. IL-22 receptor expression is absent on immune cells, but is instead restricted to the tissues, providing signaling directionality from the immune system to the tissues. Through Stat3

Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.

Shomyseh Sanjabi et al.

Current opinion in pharmacology, 9(4), 447-453 (2009-06-02)

Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other

Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

M H Xie et al.

The Journal of biological chemistry, 275(40), 31335-31339 (2000-07-06)

We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.

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