I4028

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

• Sinonimo/i: Anti-IL-18 Receptor
• Numero MDL: MFCD02096767
• Codice UNSPSC: 51111800
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 70625.111, monoclonal
• Stato: lyophilized powder
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable (2.5μg/SUP>10^{6 cell)}; immunocytochemistry: 8-25 μg/mL; immunohistochemistry: 8-25 μg/mL
• Isotipo: IgG1
• N° accesso UniProt: Q13478
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... IL18R1(8809)

Descrizione

Descrizione generale

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogeno

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Azioni biochim/fisiol

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Nota sulla preparazione

Purified using protein G.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable