Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

I0406

Sigma-Aldrich

IL-6 rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Sinonimo/i:

Interleukin-6 from rat

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Numero MDL:
MFCD01323739
Codice UNSPSC:
12352202
NACRES:
NA.77

Nome del prodotto

Interleukin-6 from rat, IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Origine biologica

rat

Livello qualitativo

200

Ricombinante

expressed in E. coli

Saggio

>97% (SDS-PAGE)

Stato

buffered aqueous solution

Potenza

0.01-0.06 ng/mL ED50

Qualità

endotoxin tested

PM

predicted mol wt ~22 kDa

Confezionamento

pkg of 10 and 50 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.01EU/mg (LAL test)

N° accesso UniProt

P20607.1

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

rat ... Il6(24498)

Categorie correlate

Azioni biochim/fisiol

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Stato fisico

Supplied as a 0.2 μm filtered solution in 50 mM sodium acetate, pH 4, with BSA as a carrier protein.

Nota sulla preparazione

Recombinant, rat Interleukin-6 is produced from a DNA sequence encoding the mature rat IL-6 protein. The methionyl form of mature rat IL-6, a 188 amino acid protein, has a predicted molecular mass of approx. 22 kDa. Rat and mouse IL-6 share 93% amino acid sequence identity.

Risultati analitici

The biological activity is measured in a cell proliferation assay using IL-6 dependent mouse plasmacytoma cell line, T1165.85.2.1.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
SLBX6207
SLBX1145
SLBS0220V
SLBR7301V
SLBQ3961V

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 4

1 of 4

IL-6 from mouse Animal-component free, recombinant, expressed in E. coli, &#8805;98% (SDS-PAGE), &#8805;98% (HPLC)

Sigma-Aldrich

SRP3330

IL-6 from mouse

Interleukin-6 human recombinant, expressed in HEK 293 cells, suitable for cell culture

Sigma-Aldrich

SCU0001

Interleukin-6 human

Rat Tumor Necrosis Factor &#945; ELISA Kit for serum, plasma and cell culture supernatant

Sigma-Aldrich

RAB0479

Rat Tumor Necrosis Factor α ELISA Kit

Siero fetale bovino USA origin, sterile-filtered, suitable for cell culture, suitable for hybridoma

Sigma-Aldrich

F2442

Siero fetale bovino

Lorena M Amaral et al.
American journal of obstetrics and gynecology, 211(2), 158-158 (2014-02-20)
Preeclampsia is a multisystem disorder recognized as hypertension with proteinuria developing >20 weeks' gestation. Preeclampsia is associated with chronic immune activation characterized by increased T and B lymphocytes, cytokines, and antibodies activating the angiotensin II type I receptor (AT1-AA). Hypertension
Elin Banke et al.
Metabolism: clinical and experimental, 63(6), 831-840 (2014-04-02)
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T
P W Bodell et al.
Journal of applied physiology (Bethesda, Md. : 1985), 106(2), 443-453 (2008-12-06)
Childhood diseases are often accompanied by chronic inflammation, which is thought to negatively impact growth. Interleukin-6 (IL-6) is typically cited as an indicator of inflammation and is linked to impaired growth. This study was designed to isolate and identify potential
Mingming Zhang et al.
PloS one, 9(10), e109146-e109146 (2014-10-03)
It has been shown that Faecalibacterium prausnitzii (F. prausnitzii), one of the dominant intestinal bacterial flora, may protect colonic mucosa against the development of inflammation and subsequent inflammatory bowel disease (IBD), with the underlying mechanisms being unclear. The impacts of
A O'Toole et al.
British journal of cancer, 111(5), 927-932 (2014-07-25)
Tumour microenvironment (TME) of advanced colorectal cancer (CRC) suppresses dendritic cell (DC) maturation. Here, our aim was to determine how the microenvironment of early-stage tumours influences DCs. Tumour-conditioned media (TCM) was generated by culturing explant tumour tissue in vitro (n=50).
Visualizza tutti i documenti correlati

Articoli

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.