HPA008612
Anti-TGFBI antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Sinonimo/i:
Anti-Beta ig-h3, Anti-Kerato-epithelin, Anti-RGD-CAP, Anti-RGD-containing collagen-associated protein, Anti-Transforming growth factor-beta-induced protein ig-h3 precursor
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Nome Commerciale
Prestige Antibodies® Powered by Atlas Antibodies
Forma fisica
buffered aqueous glycerol solution
Reattività contro le specie
human
Convalida avanzata
independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
tecniche
immunohistochemistry: 1:500- 1:1000
Sequenza immunogenica
DHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKD
N° accesso UniProt
applicazioni
research pathology
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TGFBI(7045)
Descrizione generale
TGFBI (transforming growth factor β induced) is a secretory protein, the secretion of which is induced by TGFβ in fibroblasts. It was first recognized in TGFβ-treated human lung adenocarcinoma cell line (A549). It is a highly conserved 68kDa protein, composed of 683 amino acids. It is predominantly expressed by fibroblasts, muscle cells and keratinocytes.
Immunogeno
Transforming growth factor-beta-induced protein ig-h3 precursor recombinant protein epitope signature tag (PrEST)
Applicazioni
Anti-TGFBI antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Azioni biochim/fisiol
TGFBI (transforming growth factor β induced) in involved in the initiation of morphongensis, inflammation, cell division, adhesion, proliferation, migration and differentiation. It acts as linker protein mediating the interaction of integrin to ECM (extracellular matrix) proteins. It is up-regulated in multiple human cancers, such as colorectal cancer, where its expression is linked to poor prognosis. It acts as a regulator of cyclins and CDKs (cyclin dependent kinases) in melanomas, and is highly secreted by metastatic melanoma cell. Thus, it facilitates growth and survival in metastatic melanoma cells. In HBV (hepatitis B virus)-related HCC (hepatocellular carcinoma), the aberrant expression of this protein is linked to the oncogenic potential of HBV S gene.
Caratteristiche e vantaggi
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST71267
Stato fisico
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Note legali
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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