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Merck
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H6036

Sigma-Aldrich

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

powder, ≥98% (HPLC)

Sinonimo/i:

PPT

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About This Item

Formula empirica (notazione di Hill):
C24H22N2O3
Numero CAS:
263717-53-9
Peso molecolare:
386.44
Numero MDL:
MFCD03453628
Codice UNSPSC:
51111800
ID PubChem:
24278470
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to tan

Solubilità

DMSO: soluble 20 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4

InChI

1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
IOTXSIGGFRQYKW-UHFFFAOYSA-N

Informazioni sul gene

human ... ESR1(2099)

Descrizione generale

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. It is also known as ESR1 (estrogen receptor). It is located on human chromosome 6q25.1.
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.

Applicazioni

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole has been used to cultivate differentiated adipocytes. It is also used in drug treatments and radioimmunoassay (RIA).

Azioni biochim/fisiol

Estrogen receptor α (ERα) is involved in immune and inflammatory responses. Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.
PPT is a specific estrogen receptor α (ERα) agonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus
Waters E M, et al.
Brain Research, 1290(11), 1-11 (2009)
Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression
Avila R M, et al.
Molecular and Cellular Endocrinology, 433(12), 35-46 (2016)
Pituitary estrogen receptor alpha is involved in luteinizing hormone pulsatility at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Proietto S, et al.
General and Comparative Endocrinology, 433(12), 35-46 (2018)
Naohito Kitamura et al.
PloS one, 4(4), e5159-e5159 (2009-04-10)
The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels. Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a constitutive constriction of cerebral
Estrogen Receptor 1 (ESR1) Enhances Slc2a4/GLUT4 Expression by a SP1 Cooperative Mechanism
Barreto-Andrade JN, et al.
International Journal of Medical Sciences, 15(12), 1320-1320 (2018)
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