GW22560F
Anti-SH3GL1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
chicken
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
rat, human, mouse
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SH3GL1(6455)
Descrizione generale
SH3GL1 (SH3-domain GRB2-like 1), also called EA2 (endophilin A2), was initially recognized as a fusion partner of MLL (mixed-lineage leukaemia) translocation in childhood leukaemia. It is the first member of the EEN/EA SH3 domain (Src homology 3 domain)-containing family of proteins. It is found in the cells of haemopoietic, fibroblast and epithelial lineage, where it resides primarily in the nucleus. In neurons and osteoclasts, its primary localization is in cytoplasm, thus suggesting its shuttles between nucleus and cytoplasm.
Applicazioni
Anti-SH3GL1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Azioni biochim/fisiol
SH3GL1 (SH3-domain GRB2-like 1) or endophilin-A2 is involved in the formation of endocytic vesicles. The protein is a 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. SH3GL1 is expressed ubiquitously. It is one of the main accessory proteins involved in clathrin-mediated endocytosis and it interacts with other endocytic proteins, such as dynamin, by its SH3 domain. SH3GL1 may be one of the pathogenic genes for idiopathic scoliosis (IS) and may be associated with adolescent idiopathic scoliosis (AIS). It may have some role in the cell cycle. SH3GL1 may be involved in the oncogenic process of gliomas.
Stato fisico
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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Jifeng Zhang et al.
Cellular signalling, 24(11), 2043-2050 (2012-07-04)
Endophilin, one of the main accessory proteins involved in clathrin-mediated endocytosis, interacts with other endocytic proteins, such as dynamin, by its SH3 domain. We previously reported that voltage-gated Ca(2+) channels are an integral part of the synaptic vesicle (SV) endocytosis
Ngai Cheung et al.
The Biochemical journal, 383(Pt 1), 27-35 (2004-06-25)
EEN (extra eleven nineteen), also known as EA2 (endophilin A2), a fusion partner of the MLL (mixed-lineage leukaemia) gene in human acute leukaemia, is a member of the endophilin A family, involved in the formation of endocytic vesicles. We present
Tao Yang et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 48(6), 435-438 (2010-07-16)
To identify whether SH3GL1 gene serves as a disease associated gene of adolescent idiopathic scoliosis (AIS). Positioning candidate cloning: "case-sibling or case-family control design" research scheme based on family constellation was designed. Fifty-six AIS patients (15 male and 41 female
Tomoo Matsutani et al.
Journal of experimental & clinical cancer research : CR, 31, 85-85 (2012-10-12)
Glioma is the most common primary malignant central nervous system tumor in adult, and is usually not curable in spite of various therapeutic approaches. Clarification of the oncogenic process in its early stage is important for the diagnosis and effective
C Giachino et al.
Genomics, 41(3), 427-434 (1997-05-01)
The Src-homology-3 domain (SH3) is an evolutionarily conserved, 50- to 60-amino-acid module carried by intracellular proteins involved in the transduction of signals for cell polarization, motility, enzymatic activation, and transcriptional regulation. The SH3 drives protein-protein interactions through binding to proline-rich
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