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GW21229

Sigma-Aldrich

Anti-CLIF antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Cycle-like factor CLIF

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-21229

tecniche

western blot: suitable

N° accesso NCBI

NP_064568.1

N° accesso UniProt

Q9H2M4

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CLIF(56938)

Immunogeno

Immunogen Sequence: GI # 9910368, sequence 8-100
Recombinant transcription factor BMAL2

Applicazioni

Anti-CLIF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

The CLIF gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors and is located on chromosome12. It helps in controlling diverse physiological processes including circadian rhythm. CLIF is expressed in endothelial cells and neurons in the brain, including the suprachiasmatic nucleus and the center of the circadian clock. In endothelial cells, it forms a heterodimer with CLOCK and up-regulates the PAI-1 gene through E-box sites. CLIF helps in regulating the circadian oscillation of PAI-1 gene expression in endothelial cells. Its expression is increased in colorectal cancer and is related to tumor invasiveness and aggressiveness.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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Gianluigi Mazzoccoli et al.
Journal of cancer research and clinical oncology, 138(3), 501-511 (2011-12-27)
Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating
K Maemura et al.
The Journal of biological chemistry, 275(47), 36847-36851 (2000-10-06)
The onset of myocardial infarction occurs frequently in the early morning, and it may partly result from circadian variation of fibrinolytic activity. Plasminogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning onset of myocardial infarction.
John A Schoenhard et al.
American journal of physiology. Cell physiology, 283(1), C103-C114 (2002-06-11)
The BMAL2 gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors, which control diverse physiological processes including circadian rhythms. We identified four novel human BMAL2 transcripts that differ by alternative splicing within their NH2-terminal regions. Divergent
M Ikeda et al.
Biochemical and biophysical research communications, 275(2), 493-502 (2000-08-31)
We isolated a human cDNA encoding a novel member of the bHLH-PAS transcription factor superfamily, BMAL2, which is highly similar to, but distinct from, BMAL1. The composite cDNA covered a 1720-bp sequence consisting of a putative 1653-bp open reading frame

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