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Key Documents

GW20074F

Sigma-Aldrich

Anti-Ceruloplasmin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Ferroxidase

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-20074F

tecniche

indirect ELISA: suitable
western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CP(1356)

Immunogeno

Ceruloplasmin native protein.
Immunogen Sequence: GI # 4557485, sequence 1-1065

Applicazioni

Anti-Ceruloplasmin antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme encoded by the CP gene in humans. It is a ferroxidase present in the cerebrospinal fluid (CSF). CP is associated with promoting the function of integrin binding, signaling and cell adhesion. The CP level is correlated negatively and indirectly with inflammation as well as fibrosis stages in male patients with chronic hepatitis B (CHB). It decreases the nitric oxide bioavailability in blood and is associated with cardiovascular disease (CVD).

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Da-Wu Zeng et al.
PloS one, 8(10), e77942-e77942 (2013-11-28)
This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis. Liver biopsy samples and sera were collected from 198
Marco Barbariga et al.
The Journal of biological chemistry, 289(6), 3736-3748 (2013-12-25)
Asparagine deamidation occurs spontaneously in proteins during aging; deamidation of Asn-Gly-Arg (NGR) sites can lead to the formation of isoAsp-Gly-Arg (isoDGR), a motif that can recognize the RGD-binding site of integrins. Ceruloplasmin (Cp), a ferroxidase present in the cerebrospinal fluid
Razvan T Dadu et al.
Circulation. Heart failure, 6(5), 936-943 (2013-07-19)
Ceruloplasmin (Cp) decreases nitric oxide bioavailability in blood and has been associated with cardiovascular disease (CVD) in clinical studies. We assessed the associations between Cp and incident heart failure (HF), death, and CVD in the Atherosclerosis Risk in Communities (ARIC)
Lingli Jiang et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G877-G886 (2011-08-20)
The Menkes copper ATPase (Atp7a) and metallothionein (Mt1a) are induced in the duodenum of iron-deficient rats, and serum and hepatic copper levels increase. Induction of a multi-copper ferroxidase (ceruloplasmin; Cp) has also been documented. These findings hint at an important
Perungavur N Ranganathan et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 25(4), 687-695 (2012-02-22)
Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption. Stringent structural or kinetic data derived from purified, native protein is however lacking, leading to the hypothesis that an alternate, undiscovered

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