GW20056A
Anti-Transcription Factor E3 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-TFE3, Anti-Transcription factor binding to IGHM enhancer 3
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
chicken
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
rat, human, mouse
Produttore/marchio commerciale
Genway 15-288-20056A
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TFE3(7030)
Immunogeno
Immunogen Sequence: GI # 8659574, sequence 432-541
Recombinant transcription factor binding to IGHM enhancer 3
Applicazioni
Anti-Transcription Factor E3 antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.
Azioni biochim/fisiol
TFE3 (Transcription factor E3) gene encodes a helix-loop-helix transcription factor that contains a helix-loop-helix domain and binds to MUE3-type E-box sequences (5′-CANNTG-3′). It plays a key role in transforming growth factor β (TGF-β) induced activation of the plasminogen activator inhibitor-1 (PAI-1) promoter. Chromosomal translocation resulting in the fusion of TFE3 gene to a novel gene, designated PRCC, is observed in papillary renal cell carcinomas. A chromosomal aberration in TFE3 is observed in patients with alveolar soft part sarcoma.
Stato fisico
Solution in phosphate buffered saline containing 0.02% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
H Beckmann et al.
Genes & development, 4(2), 167-179 (1990-02-01)
The muE3 motif within the immunoglobulin heavy-chain enhancer is required for full enhancer activity and is known to bind one, or perhaps a family, of related ubiquitous nuclear proteins. Here, we present the isolation of a cDNA that encodes an
P Argani et al.
The American journal of pathology, 159(1), 179-192 (2001-07-05)
The unbalanced translocation, der(17)t(X;17)(p11.2;q25), is characteristic of alveolar soft part sarcoma (ASPS). We have recently shown that this translocation fuses the TFE3 transcription factor gene at Xp11.2 to ASPL, a novel gene at 17q25. We describe herein eight morphologically distinctive
M A Weterman et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(26), 15294-15298 (1996-12-24)
The (X;1)(p11;q21) translocation is a recurrent chromosomal abnormality in a subset of human papillary renal cell carcinomas, and is sometimes the sole cytogenetic abnormality present. Via positional cloning, we were able to identify the genes involved. The translocation results in
X Hua et al.
Genes & development, 12(19), 3084-3095 (1998-10-09)
Members of the TGF-beta superfamily influence a broad range of biological activities including stimulation of wound healing and inhibition of cell growth. TGF-beta signals through type I and II receptor serine/ threonine kinases and induces transcription of many genes including
J Clark et al.
Oncogene, 15(18), 2233-2239 (1997-12-11)
We demonstrate that the cytogenetically defined translocation t(X;1)(p11.2;p34) observed in papillary renal cell carcinomas results in the fusion of the splicing factor gene PSF located at 1p34 to the TFE3 helix-loop-helix transcription factor gene at Xp11.2. In addition we define
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