Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

G4535

Sigma-Aldrich

[D-Lys3]-GHRP-6

synthetic, lyophilized powder

Sinonimo/i:

[His1, D-Lys3, Lys6]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2, [D-Lys3]-Growth Hormone Releasing Peptide 6

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.32

Origine biologica

synthetic

Livello qualitativo

Forma fisica

lyophilized powder

N° accesso UniProt

Temperatura di conservazione

−20°C

Stringa SMILE

NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H](N)Cc6c[nH]cn6)C(N)=O

InChI

1S/C49H63N13O6/c50-20-10-8-18-39(44(53)63)58-47(66)41(22-30-12-2-1-3-13-30)61-49(68)43(24-32-27-56-38-17-7-5-15-35(32)38)62-46(65)40(19-9-11-21-51)59-48(67)42(23-31-26-55-37-16-6-4-14-34(31)37)60-45(64)36(52)25-33-28-54-29-57-33/h1-7,12-17,26-29,36,39-43,55-56H,8-11,18-25,50-52H2,(H2,53,63)(H,54,57)(H,58,66)(H,59,67)(H,60,64)(H,61,68)(H,62,65)/t36-,39-,40+,41+,42+,43-/m0/s1
MGSNWNLPMHXGDD-DFWOJPNQSA-N

Informazioni sul gene

human ... GHRH(2691)

Amino Acid Sequence

His-Trp-Lys-Trp-Phe-Lys-NH2

Descrizione generale

[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.

Applicazioni

[D-Lys3]-GHRP-6 has been used:
  • to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
  • as an antagonist of growth hormone secretagogue receptor (GHS-R)
  • as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)

[D-Lys3]-GHRP6 has been used-
  • to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells
  • for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio

Azioni biochim/fisiol

[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.
[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca2+ and Na+ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 4

1 of 4

Adasue Magdaleno-Méndez et al.
Endocrine, 48(3), 929-936 (2014-08-26)
A variety of ion channels are expressed in the plasma membrane of somatotropes within the anterior pituitary gland. Modification of these channels is linked to intracellular Ca2+ levels and therefore to hormone secretion. Previous investigations have shown that the gut-derived
Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway
Lin Y, et al.
Cell communication and signaling : CCS, 17(1), 1-14 (2019)
K Veeraragavan et al.
Life sciences, 50(16), 1149-1155 (1992-01-01)
The synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP, Growth Hormone-Releasing Peptide), has no structural similarities with any of the GH-releasing peptides known and its action in releasing GH is by a complementary but yet not clearly defined action on the pituitary as well
Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin
Journal of Cystic Fibrosis, 18(4), 557-565 (2019)
Xingshen Sun et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18(4), 557-565 (2019-02-11)
Insulin secretion is insufficient in cystic fibrosis (CF), even before diabetes is present, though the mechanisms involved remain unclear. Acyl-ghrelin (AG) can diminish insulin secretion and is elevated in humans with CF. We tested the hypothesis that elevated AG contributes

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.