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F7807

Sigma-Aldrich

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinonimo/i:

17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase

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About This Item

Numero CAS:
55976-95-9
Classificazione EC (Enzyme Commission):
1.1.1.188 (BRENDA, IUBMB)
Numero MDL:
MFCD00900598
Codice UNSPSC:
12352204
NACRES:
NA.54

Ricombinante

expressed in E. coli

Livello qualitativo

200

Descrizione

contains a C-terminal hexahistidine tag

Saggio

≥90% (SDS-PAGE)

Stato

liquid

Attività specifica

≥0.4 μmol/mg protein

PM

~37 kDa

N° accesso NCBI

NP_003730

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... AKR1C3(8644)

Applicazioni

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Azioni biochim/fisiol

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Definizione di unità

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
100M1712

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Trevor M Penning et al.
Annals of the New York Academy of Sciences, 1155, 33-42 (2009-03-03)
Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type
[Prostaglandin synthases with thioredoxin domain].
Kikuko Watanabe
Seikagaku. The Journal of Japanese Biochemical Society, 82(11), 1041-1046 (2011-01-14)
Agnieszka Waclawik et al.
Reproduction (Cambridge, England), 140(4), 613-622 (2010-07-10)
Oxytocin (OXT) and tumor necrosis factor α (TNF) have been implicated in the control of luteolysis by stimulating endometrial secretion of luteolytic prostaglandin F(2α) (PGF(2α)). Nevertheless, OXT concentration in porcine uterine lumen increases markedly on days 11-12 of pregnancy, and
R J Phillips et al.
Molecular human reproduction, 17(1), 1-13 (2010-07-03)
Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and
Keishi Yamaguchi et al.
Journal of synchrotron radiation, 18(1), 66-69 (2010-12-21)
Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F(2α) from PGH(2) have been determined in the presence or absence of
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