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Key Documents

Altri documenti

D1822

Sigma-Aldrich

Doxycycline monohydrate

Sinonimo/i:

6-Deoxy-5-oxytetracycline monohydrate, Doxycycline

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About This Item

Formula empirica (notazione di Hill):
C22H24N2O8 · H2O
Numero CAS:
17086-28-1
Peso molecolare:
462.45
Numero MDL:
MFCD02682958
Codice UNSPSC:
51284030
ID PubChem:
329798712
NACRES:
NA.85

Forma fisica

powder or crystals

Livello qualitativo

200

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

−20°C

Stringa SMILE

O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14

InChI

1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
XQTWDDCIUJNLTR-CVHRZJFOSA-N

Informazioni sul gene

human ... MMP1(4312) , MMP13(4322) , MMP7(4316) , MMP8(4317)

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Categorie correlate

Applicazioni

  • In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
  • It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
  • It has also been used as an antimicrobial agent.

Azioni biochim/fisiol

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Supelco

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Demeclocycline hydrochloride hydrate

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Sigma-Aldrich

87128

Tetracycline

USP

USP

1226014

Doxycycline Related Compound A

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Sigma-Aldrich

Y1896

Yeast Synthetic Drop-out Medium Supplements

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Sigma-Aldrich

T7660

Tetracycline hydrochloride

Tetracycline 98.0-102.0% (HPLC)

Sigma-Aldrich

T3258

Tetracycline

I Chopra et al.
Microbiology and molecular biology reviews : MMBR, 65(2), 232-60 (2001-05-31)
Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.
Li HT, et al.
The Biochemical Journal, 467, 507-515 (2015)
In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.
Gomi H, et al.
Antimicrobial Agents and Chemotherapy, 45, 212-216 (2001)
Uninterpretable cerebrospinal fluid absorbance scan caused by doxycycline therapy.
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Conventional oral administration of antifilariasis drugs results in nonspecific targeting of the drugs and the intradermal delivery of nanoparticles with sizes of <100 nm could be used to improve lymphatic uptake. This study investigated the combination of nanosuspension and dissolving
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