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D0633

Sigma-Aldrich

7-(2,3-Dihydroxypropyl)theophylline

Sinonimo/i:

7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline

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About This Item

Formula empirica (notazione di Hill):
C10H14N4O4
Numero CAS:
479-18-5
Peso molecolare:
254.24
Beilstein:
284563
Numero CE:
207-526-1
Numero MDL:
MFCD00005759
Codice UNSPSC:
41106305
ID PubChem:
24893280
NACRES:
NA.77

Forma fisica

powder

Punto di fusione

161-162 °C (lit.)

Stringa SMILE

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3
KSCFJBIXMNOVSH-UHFFFAOYSA-N

Informazioni sul gene

human ... PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Azioni biochim/fisiol

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Caratteristiche e vantaggi

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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F Siepmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 216-222 (2009-09-10)
Kollidon SR-based matrix tablets containing various amounts of diprophylline were prepared and thoroughly characterized in vitro. This includes drug release measurements in 0.1M HCl and phosphate buffer pH 7.4, monitoring of changes in the tablet's height and diameter, morphology as
Sinan Güres et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(1), 122-129 (2011-10-20)
The aim of this study was to use a mechanistically realistic mathematical model based on Fick's second law to quantitatively predict the release profiles from solid lipid extrudates consisting of a ternary matrix. Diprophylline was studied as a freely water-soluble
Wei-Shan Huang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 795(2), 329-335 (2003-10-03)
A simple micellar electrokinetic chromatography is described for well resolution of theophylline, dyphylline and caffeine. The separation was performed at 25 degrees C using a background electrolyte consisting of 10mM borate buffer at pH 9 and 40 mM sodium dodecyl
Mario Grassi et al.
International journal of pharmaceutics, 276(1-2), 107-114 (2004-04-29)
A mathematical model able to describe the release kinetics of two model drugs (Diprophylline and Theophylline) from partially coated hydroxypropylmethylcellulose (HPMC, Methocel) K4M) matrices is presented. As solvent interaction with the system and drug release can only take place in
The AARP Guide to Pills: Essential Information on More Than 1,200 Prescription and Nonprescription Medicines, Including Generics, 302-302 (2006)
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