D054

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), solid

• Sinonimo/i: R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
• Formula empirica (notazione di Hill): C₁₇H₁₈ClNO · HCl
• Numero CAS: 125941-87-9
• Peso molecolare: 324.24
• Numero MDL: MFCD00069249
• Codice UNSPSC: 12352200
• ID PubChem: 24277910
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Attività ottica: [α]/D +32.1°, c = 1 in DMF(lit.)
• Condizioni di stoccaggio: desiccated; protect from light
• Colore: white
• Solubilità: H₂O: >5 mg/mL
• Stringa SMILE: Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
• InChI: 1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1; OYCAEWMSOPMASE-XFULWGLBSA-N
• Informazioni sul gene: human ... DRD1(1812)

Descrizione

Applicazioni

R(+)-SCH-23390 hydrochloride has been used:

• for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
• as a D1 receptor-selective antagonist for intracranial drug infusions
• as an antagonist of D1 receptor to study its effect on learning ability in fish

Azioni biochim/fisiol

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Caratteristiche e vantaggi

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Note legali

Sold with the permission of Schering-Plough.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)