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C5624

Sigma-Aldrich

Cryptotanshinone

≥98% (HPLC)

Sinonimo/i:

1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione, Cryptotanshinon, Tanshinone c

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About This Item

Formula empirica (notazione di Hill):
C19H20O3
Numero CAS:
35825-57-1
Peso molecolare:
296.36
Numero MDL:
MFCD07636810
Codice UNSPSC:
12352200
ID PubChem:
329775097
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D -80 to -99°, c = 0.5 in chloroform-d

Condizioni di stoccaggio

desiccated
protect from light

Colore

orange-brown

Solubilità

DMSO: ≥5 mg/mL

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Temperatura di conservazione

2-8°C

Stringa SMILE

C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23

InChI

1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
GVKKJJOMQCNPGB-JTQLQIEISA-N

Azioni biochim/fisiol

Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
116M4756V
075M4746V
082M4739V
101M4722V
010M4747

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Stattic ≥98% (HPLC), powder

Sigma-Aldrich

S7947

Stattic

Sistema di filtrazione sotto vuoto Stericup® Quick Release Millipore® pore size 0.22 μm, polyethersulfone membrane, funnel capacity 500 mL, pack of 12 ea

Millipore

S2GPU05RE

Sistema di filtrazione sotto vuoto Stericup® Quick Release Millipore®

Berberine chloride form

Sigma-Aldrich

B3251

Berberine chloride form

Fu-Lin Zheng et al.
Chinese medical journal, 124(24), 4293-4298 (2012-02-22)
Cryptotanshinone (CT) is the major active constituent of Salvia miltiorrhiza Bunge. The present study was carried out to investigate the effects of CT on rats with adjuvant arthritis (AA). AA was induced by the metatarsal footpad injection with complete Freund's
Shuangtao Ma et al.
Molecular medicine reports, 6(1), 145-150 (2012-04-17)
Cryptotanshinone is an active ingredient of Salvia miltiorrhiza that has been used in traditional Chinese medicine for treating cardiovascular disorders. Thus, we investigated the effects of cryptotanshinone on cardiac fibrosis induced by isoprenaline and examined whether cardiac matrix metalloproteinase (MMP)-2
Wenxing Chen et al.
Cancer prevention research (Philadelphia, Pa.), 5(5), 778-787 (2012-04-12)
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, the underlying mechanism is not well understood. Here, we show that CPT induced caspase-independent cell death in human tumor cells (Rh30, DU145
Wentao Bi et al.
Talanta, 85(1), 701-706 (2011-06-08)
Ionic liquid-based extraction of medicinal or useful compounds from plants was investigated as an alternative to supercritical fluid, cloud point and conventional organic solvent extractions. The method integrated extraction and preconcentration. Medicinal products were first extracted by an ionic liquid
Yingjie Wei et al.
Molecules (Basel, Switzerland), 17(7), 8617-8632 (2012-07-20)
The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds
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