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C125

(±)-CGP-12177A

Name: (±)-CGP-12177A
Brand: SIGMA

≥98% (HPLC), solid

Sinonimo/i:

(±)-CGP-12177 hydrochloride, 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1, 3-dihydro-2H-benzimidazol-2-one hydrochloride

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About This Item

Formula empirica (notazione di Hill):

C₁₄H₂₁N₃O₃ · HCl

Numero CAS:

64208-32-8

Peso molecolare:

315.80

Numero MDL:

MFCD00069230

Codice UNSPSC:

12352200

ID PubChem:

24277768

NACRES:

NA.77

Prodotti consigliati

Slide 1 of 1

1 of 1

Sigma-Aldrich

242985

Alconox^® detergent

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white

Solubilità

DMSO: >10 mg/mL

Stringa SMILE

Cl.CC(C)(C)NCC(O)COc1cccc2NC(=O)Nc12

InChI

1S/C14H21N3O3.ClH/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10;/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19);1H
YQVFCYCTITZLSX-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB1(153) , ADRB2(154) , ADRB3(155)

Applicazioni

(±)-CGP-12177A has been used as a β-Adrenergic receptor agonist:

to evaluate the dissociation constant (Kd) by frontal affinity chromatography
to study its cardiostimulant effects on rat ventricular cardiomyocytes
to study its binding affinity in α_1D-adrenoceptors expressed in rat BHK-21 cells

Azioni biochim/fisiol

β-adrenoceptor nonconventional partial agonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Contribution of beta-adrenoceptor subtypes to relaxation of colon and oesophagus and pacemaker activity of ureter in wildtype and beta(3)-adrenoceptor knockout mice.

J Oostendorp et al.

British journal of pharmacology, 130(4), 747-758 (2000-06-24)

The smooth muscle relaxant responses to the mixed beta(3)-, putative beta(4)-adrenoceptor agonist, (-)-CGP 12177 in rat colon are partially resistant to blockade by the beta(3)-adrenoceptor antagonist SR59230A suggesting involvement of beta(3)- and putative beta(4)-adrenoceptors. We now investigated the function of

In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues.

P Oliver et al.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 24(4), 423-428 (2000-05-11)

To assess the effect of chronic treatment with CGP-12177 a beta3-adrenergic receptor (AR) agonist with beta2/beta1-AR antagonist action, on the expression of the leptin gene and of genes coding for uncoupling proteins (ucp1, ucp2 and ucp3) in brown and white

Comparison of the binding affinity of CGP-12177A at recombinant rat alpha(1D)-adrenoceptors expressed in BHK-21 cell membranes and alpha(1)-adrenoceptors present in rat cerebral cortex membranes.

Maura Floreani et al.

European journal of pharmacology, 590(1-3), 303-309 (2008-07-01)

Recent in vitro studies, performed in rat aorta, mesenteric and intrapulmonary arteries, and human pulmonary artery, demonstrated that the beta-adrenoceptor ligand CGP-12177A (4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one) is also provided with antagonist or partial agonist properties at alpha(1)-adrenoceptors. These observations were supported by estimates

Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology.

Clive J Lewis et al.

British journal of pharmacology, 141(5), 813-824 (2004-02-06)

1. CGP 12177A mediates cardiostimulation by activation of the 'putative' beta(4)-adrenoceptor; however, it has recently been reported that disruption of the beta(1)-adrenoceptor gene abolishes this effect. We have adenovirally overexpressed beta(1)-adrenoceptors in isolated, cultured adult rat ventricular cardiomyocytes and observed

The effects of beta-adrenoceptor agonists on KCl-induced rhythmic contraction in the ureter of guinea pig.

Y Yamamoto et al.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 36(1), 13-19 (2000-06-01)

In the present study, we tried to determine what effects were induced by beta-adrenoceptor agonists on 40 mM KCl-induced rhythmic contraction and to clarify which beta-adrenoceptor subtypes are involved in the regulation of ureter motility in the guinea pig by

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