C0493

Monoclonal Anti-Calcium Sensing Receptor

clone HL1499 (6D4-3F4-6C4), purified from hybridoma cell culture

• Sinonimo/i: Anti-CAR, Anti-EIG8, Anti-FHH, Anti-FIH, Anti-GPRC2A, Anti-HHC, Anti-HHC1, Anti-HYPOC1, Anti-NSHPT, Anti-PCAR1, Anti-hCasR
• Numero MDL: MFCD02262635
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: HL1499 (6D4-3F4-6C4), monoclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: rabbit, rat, mouse, human
• tecniche: immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 3-6 μg/mL using total extract from rat kidney
• Isotipo: IgG1
• N° accesso UniProt: P41180
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CASR(846) ; mouse ... Casr(12374) ; rat ... Casr(24247)

Descrizione

Descrizione generale

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

Immunogeno

peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.

Applicazioni

Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:

• Indirect ELISA
• Immunoblotting
• Immunocytochemistry
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
• Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney

Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.

Azioni biochim/fisiol

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable