B0684
Anti-Bad antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-BBC2, Anti-BCL2L8
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
lyophilized powder
Reattività contro le specie
mouse, human
tecniche
western blot: 1 μg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... BAD(572)
mouse ... Bad(12015)
Descrizione generale
Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.
Immunogeno
synthetic peptide corresponding to amino acids 1-21 of human Bad conjugated to KLH.
Applicazioni
Anti-Bad antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL
Azioni biochim/fisiol
The protein encoded by this gene forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis.Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor. Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.
Stato fisico
lyophilized from a 0.2 μm filtered solution of phosphate buffered saline (PBS) and 5% trehalose
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
K Wang et al.
Molecular and cellular biology, 18(10), 6083-6089 (1998-09-19)
The BCL-2 family of proteins is comprised of proapoptotic as well as antiapoptotic members (S. N. Farrow and R. Brown, Curr. Opin. Genet. Dev. 6:45-49, 1996). A prominent death agonist, BAX, forms homodimers and heterodimerizes with multiple antiapoptotic members. Death
Lishuai Feng et al.
International journal of molecular medicine, 42(2), 1074-1085 (2018-05-12)
Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the
E Yang et al.
Cell, 80(2), 285-291 (1995-01-27)
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening and lambda expression cloning identified a novel interacting protein, Bad, whose homology to Bcl-2 is limited to the BH1 and BH2 domains.
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Z N Oltvai et al.
Cell, 74(4), 609-619 (1993-08-27)
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino
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