AV45322
Anti-OLR1 antibody produced in rabbit
IgG fraction of antiserum
Sinonimo/i:
Anti-CLEC8A, Anti-LOX1, Anti-Oxidized low density lipoprotein (lectin-like) receptor 1, Anti-SCARE1
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
IgG fraction of antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
20 kDa
Reattività contro le specie
human
Concentrazione
0.5 mg - 1 mg/mL
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... OLR1(4973)
Immunogeno
Synthetic peptide directed towards the N terminal region of human OLR1
Applicazioni
Anti-OLR1 antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.
Azioni biochim/fisiol
Oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1; LOX1) is a receptor for low density lipoprotein (LDL) that belongs to C-type lectin superfamily. It binds, internalizes and degrades oxidized LDL and has a role as scavenger receptor. It may be involved in the regulation of Fas-induced apoptosis. Mutations in OLR1 gene are associated with atherosclerosis and myocardial infarction.
Sequenza
Synthetic peptide located within the following region: QANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQ
Stato fisico
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Zufeng Ding et al.
Scientific reports, 3, 2091-2091 (2013-06-29)
Here we demonstrate that "concentration polarization" of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and activates LOX-1 dependent autophagy and apoptosis. We also show that ox-LDL concentration polarization occurs on the surface
Angela Pirillo et al.
Mediators of inflammation, 2013, 152786-152786 (2013-08-13)
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on
Ming-Sheng Zhou et al.
American journal of hypertension, 27(6), 873-880 (2014-01-15)
Current treatment for the secondary prevention of cardiovascular diseases frequently involves the prescription of several combination therapies, particularly antihypertensive medications and HMG-CoA reductase inhibitor. We have previously shown that in salt-sensitive hypertension either a statin or the calcium channel blocker
Miyuki Kumano-Kuramochi et al.
Biochemical and biophysical research communications, 434(3), 594-599 (2013-04-16)
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1.
Deenadayalan Bakthavatsalam et al.
FEBS letters, 588(13), 2133-2140 (2014-05-23)
Lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a scavenger receptor that binds oxidized low-density lipoprotein (OxLDL) and has a role in atherosclerosis development. The N-terminus intracellular region (cytoplasmic domain) of LOX-1 mediates receptor internalization and trafficking, potentially through intracellular protein
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