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Key Documents

A7469

Sigma-Aldrich

L-Alanine

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Sinonimo/i:

(S)-2-Aminopropionic acid, L-α-Aminopropionic acid

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About This Item

Formula empirica (notazione di Hill):
C3H7NO2
Numero CAS:
Peso molecolare:
89.09
Beilstein:
1720248
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.26

product name

L-Alanine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Origine biologica

non-animal source

Livello qualitativo

agenzia

meets EP testing specifications
meets USP testing specifications

Nome Commerciale

BioXtra

Saggio

98.5-101.0%

Forma fisica

powder

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

Colore

white

Solubilità

H2O: 100 mg/mL

applicazioni

peptide synthesis
pharmaceutical (small molecule)

Stringa SMILE

C[C@H](N)C(O)=O

InChI

1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
QNAYBMKLOCPYGJ-REOHCLBHSA-N

Informazioni sul gene

human ... CA1(759) , CA2(760)

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Applicazioni

L-Alanine has been used for tissue culture technique as a media component. It has been used as a media component for the growth of adult mouse keratinocytes.

Azioni biochim/fisiol

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle. It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver. Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.

Applicazioni

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Supelco

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Serial Cultivation of Primary Adult Murine Keratinocytes
Richard P. Redvers and Pritinder Kaur
Methods in Molecular Biology, 15-22 (2005)
Alanine and Glutamine Synthesis and Release from Skeletal
Muscle
ALAN J. GARBER
The Journal of Biological Chemistry, 251(3) (1976)
A primary culture technique of adult retina for regeneration studies on adult CNS neurons
Alexandra Kretz
Nature Protocols, 131-140 (2007)
Muscle alanine synthesis and hepatic gluconeogenesis
Snell K
Biochemical Society Transactions, 8(2), 205-213 (1980)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1) (2009)

Articoli

Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.

Chromatograms

application for HPLC

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