A4308

Autocamtide 2-related inhibitory peptide

≥97% (HPLC), lyophilized powder

• Sinonimo/i: [Ala⁹]-Autocamtide 2, AIP
• Formula empirica (notazione di Hill): C₆₄H₁₁₆N₂₂O₁₉
• Numero CAS: 167114-91-2
• Peso molecolare: 1497.74
• Codice UNSPSC: 12352202
• ID PubChem: 329770854
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: lyophilized powder
• PM: ~_1.5 kDa
• Composizione: Peptide content, ≥70%
• Solubilità: H₂O: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)CC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O
• InChI: 1S/C65H114N20O21/c1-32(2)28-46(63(105)106)85-54(96)36(7)78-62(104)45(31-52(93)94)84-56(98)38(33(3)4)30-47(86)34(5)76-59(101)43(19-22-50(89)90)81-55(97)37(18-21-49(69)88)29-48(87)40(16-12-26-74-64(70)71)79-60(102)42(17-13-27-75-65(72)73)83-61(103)44(20-23-51(91)92)80-53(95)35(6)77-58(100)41(15-9-11-25-67)82-57(99)39(68)14-8-10-24-66/h32-46H,8-31,66-68H2,1-7H3,(H2,69,88)(H,76,101)(H,77,100)(H,78,104)(H,79,102)(H,80,95)(H,81,97)(H,82,99)(H,83,103)(H,84,98)(H,85,96)(H,89,90)(H,91,92)(H,93,94)(H,105,106)(H4,70,71,74)(H4,72,73,75)/t34-,35-,36-,37+,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1; COEHZSYVSXUBHI-CYZNULJVSA-N
• Informazioni sul gene: human ... CAMK2A(815) , CAMK2B(816) , CAMK2D(817) ; mouse ... CAMK2A(12322) , CAMK2B(12323) , CAMK2D(108058) ; rat ... CAMK2A(25400) , CAMK2B(24245) , CAMK2D(24246)

Descrizione

Amino Acid Sequence

Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Applicazioni

Autocamtide 2-related inhibitory peptide has been used:

• To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
• To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
• To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII

Azioni biochim/fisiol

Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.

Potent inhibitor of calmodulin-depentent protein kinase II.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)