A3672
Azurin
from Pseudomonas aeruginosa, lyophilized powder
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Prodotti consigliati
Origine biologica
Pseudomonas aeruginosa
Livello qualitativo
Forma fisica
lyophilized powder
Composizione
Protein, ≥65% Lowry
Concentrazione
≥65.0% (Lowry)
tecniche
toxicology assay: suitable
Solubilità
water: soluble 1—1.1 mg/mL, clear, blue (light blue to blue)
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
Pseudomonas aeruginosa ... AZU(878046)
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Descrizione generale
Research area: Apoptosis. Azurinis a periplasmic protein and is a homotetramer.
Applicazioni
Azurin has been used:
- in the cytotoxicity and cell viability studies in human osteosarcoma cell line
- for the functionalization of silicon nitride cantilevers for interaction studies
- for coating gold surface and insulating functionalized oxide surfaces of silicon oxide and mica
Azioni biochim/fisiol
Azurin acts as an electron donor for nitrite reductase in bacterial denitrification process. It exhibits anticancer activity as it hampers various independent signaling pathways associated with cancer progression. It binds to tumor suppressor protein p53 and induces cancer cell apoptosis or stalls cancer cell growth. Azurin disrupts angiogenesis by reducing the activity of VEGFR-2tyrosine kinase thereby inhibiting tumor growth. It has been observed to show cytotoxicity in human breast cancer cells and human melanoma cells.
Azurin is a metalloprotein in the family of cupredoxins. It preferentially enters cancer cells over normal cells and induces apoptosis. Azurin has structural similarities to ephrinB2, and in fact binds the ephrin receptor tyrosine kinase EphB2 to initiate cell signaling that is involved in cancer progression. Azurin inhibits autophosphorlyation of the EphB2 tyrosine residue, interfering with upstream cell signaling and contributing to cancer cell growth inhibition.
Stato fisico
Lyophilized powder containing ammonium acetate buffer salts.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Yunlei Zhang et al.
Applied and environmental microbiology, 78(21), 7603-7610 (2012-08-28)
Many studies have demonstrated that intravenously administered bacteria can target and proliferate in solid tumors and then quickly be released from other organs. Here, we employed the tumor-targeting property of Escherichia coli Nissle 1917 to inhibit mouse B16 melanoma and
Krzysztof Kazimierczuk et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 223, 1-10 (2012-09-11)
The resolution of multidimensional NMR spectra can be severely limited when regular sampling based on the Nyquist-Shannon theorem is used. The theorem binds the sampling rate with a bandwidth of a sampled signal and thus implicitly creates a dependence between
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells
Yang DS, et al.
Pharmacological Research, 52(5), 413-421 (2005)
Ajay Kumar Yagati et al.
Biosensors & bioelectronics, 40(1), 283-290 (2012-08-14)
We developed a nanoscale memory device consisting of signal-responsive biomaterial, which is capable of switching physical properties (such as electrical/electrochemical, optical, and magnetic) upon application of appropriate electrical signals to perform memory switching. Here, we propose a highly robust surface-confined
Daniel Raimunda et al.
Metallomics : integrated biometal science, 5(2), 144-151 (2013-01-29)
Pseudomonas aeruginosa, an opportunistic pathogen, has two transmembrane Cu(+) transport ATPases, CopA1 and CopA2. Both proteins export cytoplasmic Cu(+) into the periplasm and mutation of either gene leads to attenuation of virulence. CopA1 is required for maintaining cytoplasmic copper levels
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.