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Key Documents

A3352

Sigma-Aldrich

Acyl-coenzyme A Synthetase from Pseudomonas sp.

≥2 units/mg protein

Sinonimo/i:

Acid: CoA ligase (AMP-forming)

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About This Item

Numero CAS:
Classificazione EC (Enzyme Commission):
Numero CE:
Numero MDL:
Codice UNSPSC:
12352204
NACRES:
NA.54

Forma fisica

powder

Livello qualitativo

Attività specifica

≥2 units/mg protein

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

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Descrizione generale

Acyl-coenzyme A synthetase belongs to adenylate-forming enzymes superfamily. It has a conserved adenosine triphosphate/adenosine monophosphate (ATP/AMP) binding motif.

Applicazioni

Acyl-coenzyme A (coA) synthetase from Pseudomonas sp. has been used:
  • as ligase in the synthesis of mevalonate derivatives of adenosine triphosphate (ATP)
  • in in vitro fatty acylation assays
  • in the synthesis of (14C)Vernoloyl-CoA (Va-CoA),(3) bisphosphonates derivatives of ATP(4) and (3H)Palmitate-CoA

Acyl-coenzyme A Synthetase may be used to study fatty acid metabolism and lipid metabolism. It has been used to study its interaction with fatty acid transport proteins, which has been found to be involved in the efficient cellular uptake of long-chain fatty acids in adipocytes .

Azioni biochim/fisiol

Acyl coenzyme A synthetase proteins are involved in regulating and facilitating long-chain fatty acid transport in mammalian cells .
Acyl-coenzyme A (CoA) synthetase (ACS) enzyme catalyzes a two-step thioesterification reaction involving the conversion of free fatty acids (FAs) to CoA esters. The substrate for ACS varies from two carbon to 26 carbon FAs. It is involved in the activation of FAs for lipid metabolism and enables FA to participate in various cellular metabolic pathways.

Definizione di unità

One unit will form 1.0 μmole of AMP and oleoyl coenzyme A from ATP and oleate at pH 8.1 at 25 °C in the presence of Coenzyme A.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
Kochan G, et al.
Journal of Molecular Biology, 388(5), 997-1008 (2009)
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di-and triphosphate; geranyl di-and triphosphate, farnesyl di-and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases: Potential relationship with the effect of bisphosphonates on osteoclasts
Sillero MAG, et al.
Biochemical Pharmacology, 78(4), 335-343 (2009)
Naohiro Kurotaki et al.
PloS one, 6(5), e20589-e20589 (2011-06-10)
The recent development of high-resolution DNA microarrays, in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped, enables the rapid identification of susceptibility genes for complex diseases. Clusters of these SNPs may show runs of homozygosity (ROHs) that
A Ruść et al.
Meat science, 89(4), 440-443 (2011-06-10)
The aim of the study was to check whether different genotypes at acyl-CoA synthetase (ACSL4 locus, SNP G2645A) are associated with pork quality. 132 (Landrace × Yorkshire) × Duroc fatteners were genotyped by originally developed PCR-RFLP method. Upon the slaughter
Michael Veit et al.
Methods in molecular biology (Clifton, N.J.), 446, 163-182 (2008-04-01)
Palmitoylation or S-acylation is the post-translational attachment of fatty acids to cysteine residues and is common among integral and peripheral mem brane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as

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