A3227

Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ trifluoroacetate salt

≥98% (HPLC), lyophilized powder, PAR4 agonist

• Sinonimo/i: AYPGKF-NH₂, PAR4-AP
• Formula empirica (notazione di Hill): C₃₄H₄₈N₈O₇ · xC₂HF₃O₂
• Numero CAS: 1228078-65-6
• Peso molecolare: 680.79 (free base basis)
• Numero MDL: MFCD04974484
• Codice UNSPSC: 12352202
• ID PubChem: 329770819
• NACRES: NA.77

Proprietà

• product name: Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ trifluoroacetate salt, ≥98% (HPLC), lyophilized powder
• Saggio: ≥98% (HPLC)
• Forma fisica: lyophilized powder
• Colore: white
• Solubilità: H₂O: >10 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
• InChI: 1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1; BGPJLFVICWHITH-HKJXYENISA-N

Descrizione

Amino Acid Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2

Descrizione generale

Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ (AYPGKF- NH₂) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.

Applicazioni

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.

AYPGKF- NH₂ may be used for probing PAR4 signaling in culture systems and in platelets.

Azioni biochim/fisiol

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)