70485
Naphthol AS-E phosphate
suitable for histology
Sinonimo/i:
KG-501
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About This Item
Formula empirica (notazione di Hill):
C17H13ClNO5P
Numero CAS:
Peso molecolare:
377.72
Beilstein:
6664478
Numero CE:
Numero MDL:
Codice UNSPSC:
12352204
ID PubChem:
NACRES:
NA.83
Prodotti consigliati
Saggio
≥80% (HPLC)
Livello qualitativo
Stato
powder
applicazioni
histology
Temperatura di conservazione
2-8°C
Stringa SMILE
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Categorie correlate
Applicazioni
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Azioni biochim/fisiol
Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.
Altre note
Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
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Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
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