484R-1

PRAME (EP461) Rabbit Monoclonal Primary Antibody

• Sinonimo/i: Preferentially-expressed Antigen in Melanoma
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP461, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (484R-14); vial of 0.1 mL concentrate Research Use Only (484R-14-RUO); vial of 0.5 mL concentrate (484R-15); vial of 1.0 mL concentrate (484R-16); vial of 1.0 mL concentrate Research Use Only (484R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (484R-17); vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO); vial of 25.0 mL pre-dilute ready-to-use (484R-10); vial of 7.0 mL pre-dilute ready-to-use (484R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• Isotipo: IgG
• Controllo: melanoma
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear

Descrizione

Descrizione generale

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.¹ PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.^2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,⁴ and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)⁵ and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,⁶ and the majority of mucosal melanomas.⁷

Qualità

• United States - IVD
• Canada - RUO
• European Union - IVD
• Japan - RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable