477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

• Sinonimo/i: Melanoma-associated antigen C2
• Codice UNSPSC: 12352203
• Clone: EP405, monoclonal
• application: IHC (p)
• Reattività contro le specie: human
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• citations: 7

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP405, monoclonal
• Descrizione: For In Vitro Diagnostic Use in Select Regions
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (477R-14); vial of 0.1 mL concentrate Research Use Only (477R-14-RUO); vial of 0.5 mL concentrate (477R-15); vial of 1.0 mL concentrate (477R-16); vial of 1.0 mL concentrate Research Use Only (477R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (477R-17); vial of 7.0 mL pre-dilute ready-to-use (477R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• Isotipo: IgG
• Controllo: seminoma
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear

Descrizione

Descrizione generale

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Qualità

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable