282200

Galangin

autophagy inducing flavonoid

• Sinonimo/i: 3,5,7-Trihydroxyflavone, Norizalpinin
• Formula empirica (notazione di Hill): C₁₅H₁₀O₅
• Numero CAS: 548-83-4
• Peso molecolare: 270.24
• Beilstein: 272179
• Numero CE: 208-960-4
• Numero MDL: MFCD00006833
• Codice UNSPSC: 41116107
• ID PubChem: 57648294
• NACRES: NA.79

Proprietà

• Saggio: ≥95% (HPLC)
• Forma fisica: powder
• Colore: yellow
• Punto di fusione: 214-215 °C (lit.)
• Stringa SMILE: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H; VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Descrizione

Descrizione generale

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Applicazioni

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Azioni biochim/fisiol

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves