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Merck
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Documenti fondamentali

230R-1

Sigma-Aldrich

Caldesmon (E89) Rabbit Monoclonal Primary Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

E89, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Stato

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (230R-14)
vial of 0.5 mL concentrate (230R-15)
bottle of 1.0 mL predilute (230R-17)
vial of 1.0 mL concentrate (230R-16)
bottle of 7.0 mL predilute (230R-18)

Produttore/marchio commerciale

Cell Marque™

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotipo

IgG

Controllo

appendix, breast

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

cytoplasmic

Categorie correlate

Descrizione generale

Caldesmon is a regulatory protein that plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle. It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.

Qualità


IVD
IVD
IVD
RUO

Linkage

Caldesmon Positive Control Slides, Product No. 230S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

Lot/Batch Number
0000292383
0000295645
0000295645
0000292383
1408304A-Z

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W Glenn McCluggage
Advances in anatomic pathology, 11(3), 162-171 (2004-04-21)
In recent years there have been a plethora of publications regarding the value of immunohistochemical studies in diagnosis in gynecological pathology. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of
Camilla E Comin et al.
The American journal of surgical pathology, 30(4), 463-469 (2006-04-21)
Although a large number of immunohistochemical markers that can facilitate the differential diagnosis between epithelioid pleural mesothelioma and lung adenocarcinoma involving the pleura have proven to be valuable, no single antibody has demonstrated absolute sensitivity and/or specificity in making this
Markku Miettinen et al.
Archives of pathology & laboratory medicine, 130(10), 1466-1478 (2006-11-09)
Gastrointestinal stromal tumors (GISTs) are specific, generally Kit (CD117)-positive, mesenchymal tumors of the gastrointestinal tract encompassing a majority of tumors previously considered gastrointestinal smooth muscle tumors. They are believed to originate from interstitial cells of Cajal or related stem cells.
K Watanabe et al.
Human pathology, 30(4), 392-396 (1999-04-20)
h-Caldesmon (h-CD) is a protein combined with actin and tropomyosin that regulates cellular contraction. h-CD has been thought to be expressed exclusively in vascular and visceral smooth muscle cells (SMC). We examined h-CD expression immunohistochemically in tumors with SMC and
Camilla E Comin et al.
The American journal of surgical pathology, 31(8), 1139-1148 (2007-08-02)
Distinguishing between epithelioid peritoneal mesothelioma and papillary serous carcinomas involving the peritoneum may be very difficult, owing to overlapping morphologic features. Immunohistochemistry may facilitate establishing a correct diagnosis, but, as no single antibody has demonstrated absolute sensitivity and specificity for

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