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03907

Sigma-Aldrich

Tioconazole

97%

Sinonimo/i:

1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole

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About This Item

Formula empirica (notazione di Hill):
C16H13Cl3N2OS
Numero CAS:
65899-73-2
Peso molecolare:
387.71
Numero CE:
265-973-8
Numero MDL:
MFCD00057276
Codice UNSPSC:
51302325
ID PubChem:
329747834
NACRES:
NA.85

Livello qualitativo

100

Saggio

≥96.5% (HPLC)
96.5-103.5% (NT)
97%

Forma fisica

powder

Colore

white to off-white

Spettro attività antibiotica

fungi
yeast

Modalità d’azione

cell membrane | interferes

Stringa SMILE

Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1

InChI

1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
QXHHHPZILQDDPS-UHFFFAOYSA-N

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Descrizione generale

Chemical structure: pyrimidine

Applicazioni

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.

Azioni biochim/fisiol

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

Confezionamento

10G

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Avvertenze

Warning

Indicazioni di pericolo

H302,H317,H361d,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Supelco

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Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
Allergic contact dermatitis from tioconazole.
A Faria et al.
Contact dermatitis, 35(4), 250-252 (1996-10-01)
Karine Bourcier et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(6), 923-929 (2010-03-23)
Imidazoles and triazoles represent major classes of antifungal azole derivatives. With respect to UDP-glucuronosyltransferase (UGT) enzymes, the drug metabolism focus has mainly concentrated on their inhibitory effects with little known about azoles as substrates for UGTs. N-Glucuronide metabolites of the
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