Y0001599

Wedelolactone

European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 7-Methoxy-5,11,12-trihydroxycoumestan
• Formula empirica (notazione di Hill): C₁₆H₁₀O₇
• Numero CAS: 524-12-9
• Peso molecolare: 314.25
• Numero MDL: MFCD07778564
• Codice UNSPSC: 41116107
• ID PubChem: 329831504
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: wedelolactone
• Produttore/marchio commerciale: EDQM
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: −20°C
• Stringa SMILE: COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3; XQDCKJKKMFWXGB-UHFFFAOYSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Wedelolactone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC₅₀ < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1