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Documenti fondamentali

Y0000668

Tibolone for system suitability

Name: Tibolone for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one

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About This Item

Formula empirica (notazione di Hill):

C₂₁H₂₈O₂

Numero CAS:

5630-53-5

Peso molecolare:

312.45

Codice UNSPSC:

41116107

NACRES:

NA.24

Prodotti consigliati

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BP848

Tibolone

Supelco

Y0002348

Tibolone

Y0000867

Sertraline for system suitability

Y0000362

Ciprofibrate

Y0001270

Timolol for system suitability

C3283000

Cyproterone acetate

A0153000

Acetylcysteine impurity D

N0845000

Nimesulide

Supelco

PHR1322

Gabapentin Related Compound A

BP669

Domperidone maleate

Grado

pharmaceutical primary standard

Famiglia di API

tibolone

Produttore/marchio commerciale

EDQM

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

Punto di fusione

165-169 °C

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

InChI

1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1
WZDGZWOAQTVYBX-XOINTXKNSA-N

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Tibolone is a synthetic steroid with weak estrogenic, androgenic, and progestogenic activity used in the treatment of menopausal syndrome. Tibolone and its metabolites induce prolactin production in human endometrial stromal cells in vitro. Sulfation plays a major role in the metabolism and regulation of the tissue-specific activity of tibolone and its metabolites.

Applicazioni

Tibolone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Consigli di prudenza

P264 - P280 - P305 + P351 + P338 - P337 + P313

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment.

Mariana Hulchiy et al.

Menopause (New York, N.Y.), 19(11), 1253-1259 (2012-06-21)

Thyroid gland dysfunction is associated with menstrual cycle disturbances, infertility, and increased risk of miscarriage, but the mechanisms are poorly understood. However, little is known about the regulation of these receptors in the uterus. The aim of this study was

The impact of six-month tibolone postmenopausal treatment on cell adhesion molecules levels.

C Zografou et al.

Clinical and experimental obstetrics & gynecology, 39(3), 337-340 (2012-11-20)

The aim of the present study was to evaluate the effects of tibolone on inter-cellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), inter-cellular adhesion molecule-2 (ICAM-2) and P-selectin levels in healthy postmenopausal women. This prospective study included 25 postmenopausal

Tibolone has anti-inflammatory effects in estrogen-deficient female rats on the natriuretic peptide system and TNF-alpha.

Ana Raquel Santos de Medeiros et al.

Regulatory peptides, 179(1-3), 55-60 (2012-09-15)

Cardiovascular and immune system abnormalities have been reported in females with estrogen deficiency. To control these disorders in post-menopausal women, hormone replacement therapy (HRT) has been used. Tibolone has been used as a HRT, but the effects of tibolone on

Influence of estrogen deficiency and tibolone therapy on trabecular and cortical bone evaluated by computed radiography system in rats.

Ana Carolina Bergmann de Carvalho et al.

Acta cirurgica brasileira, 27(3), 217-222 (2012-03-31)

To verify the effects of tibolone administration on trabecular and cortical bone of ovariectomized female rats by computed radiography system (CRS). The experiment was performed on two groups of rats previously ovariectomized, one received tibolone (OVX+T) while the other did

Hearing levels in menopausal women and the effect of tibolone on audiological functions.

N Köşüş et al.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 32(3), 294-297 (2012-03-01)

The aim of this study was to examine the hearing levels of menopausal and premenopausal women of the same age and to evaluate the effect of tibolone on hearing. The study involved 83 postmenopausal women. Cases using tibolone were grouped

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