SMB01318

3-Hydroxydesloratadine

• Sinonimo/i: 3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
• Formula empirica (notazione di Hill): C₁₉H₁₉ClN₂O
• Numero CAS: 119410-08-1
• Peso molecolare: 326.82
• Numero MDL: MFCD00878381
• NACRES: NA.77

Proprietà

• Descrizione: Modulation and Signaling
• Livello qualitativo: 100
• Saggio: ≥90%
• Forma fisica: solid
• tecniche: HPLC: suitable
• Colore: pale yellow to off-white
• Temperatura di conservazione: −20°C
• InChI: 1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2; NDFMTPISBHBIKE-UHFFFAOYSA-N

Descrizione

Descrizione generale

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Applicazioni

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Azioni biochim/fisiol

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Caratteristiche e vantaggi

• High quality compound suitable for multiple research applications
• Compatible with a wide variety of chromatographic and spectrometry techniques

Altre note

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This product is intended for research purposes only, and it is not meant for human consumption.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable