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Key Documents

PHR2020

Supelco

Candesartan Cilexetil Related Compound F

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

(1-(Cyclohexyloxycarbonyloxy]ethyl 2-ethoxy-1-{[2′-(2-ethyl-2H-tetrazol-5-yl)-biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

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About This Item

Formula empirica (notazione di Hill):
C35H38N6O6
Peso molecolare:
638.71
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to USP 1087869

Famiglia di API

candesartan

CdA

current certificate can be downloaded

Confezionamento

pkg of 20 mg

applicazioni

pharmaceutical small molecule

Formato

neat

Temperatura di conservazione

2-8°C

Descrizione generale

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Candesartan cilexetil is a selective antagonist to Angiotensin II receptors, that plays a crucial role in blood pressure regulation and sodium homeostasis, and is popularly used for the treatment of hypertension, diabetic nephropathy and congestive heart failure.

Applicazioni

Candesartan cilexetil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAB4750 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: a placebo-controlled, forced titration study
Lacourciere Y and Asmar R
American Journal of Hypertension, 12(12), 1181-1187 (1999)
Determination of candesartan cilexetil in tablets by spectrofluorimetry
Sakur AA and Hanan F
International Journal of Pharmaceutical Sciences Review and Research, 4(2), 60-63 (2010)
Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist
Otsuka M, et al.
Thorax, 59(1), 31-38 (2004)
Characterization of conjugated metabolites of a new angiotensin II receptor antagonist, candesartan cilexetil, in rats by liquid chromatography/electrospray tandem mass spectrometry following chemical derivatization
Kondo T, et al.
Journal of Mass Spectrometry : Jms, 31(8), 873-878 (1996)
Q-Analysis Spectrophotometric methods for estimation of Candesartan Cilexetil and Hydrochlorothiazide in tablet dosage form
Jignesh P, et al.
Journal of Chemical and Pharmaceutical Research, 2(3), 10-14 (2010)

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