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D2950000

Disulfiram

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

Tetraethylthiuram disulfide, Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Formula condensata:
(C2H5)2NCSS2CSN(C2H5)2
Numero CAS:
97-77-8
Peso molecolare:
296.54
Beilstein:
1712560
Numero CE:
202-607-8
Numero MDL:
MFCD00009048
Codice UNSPSC:
41116107
ID PubChem:
329798762
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

disulfiram

Produttore/marchio commerciale

EDQM

Punto di fusione

69-71 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
AUZONCFQVSMFAP-UHFFFAOYSA-N

Informazioni sul gene

human ... ALDH2(217)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Alcohol dehydrogenase inhibitor.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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Descrizione
Determinazione del prezzo

Avvertenze

Warning

Indicazioni di pericolo

H302,H317,H373,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Sigma-Aldrich

222569

Fomepizole

Daidzin ≥95.0% (HPLC)

Sigma-Aldrich

30408

Daidzin

SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

Sodium diethyldithiocarbamate trihydrate ACS reagent

Sigma-Aldrich

228680

Sodium diethyldithiocarbamate trihydrate

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Drug discovery today, 13(15-16), 716-722 (2008-06-27)
The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used clinically. This strategy is time-consuming and expensive. Recent studies have disclosed a surprising, but mechanistically consistent, anticancer
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 953-960 (2013-04-26)
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anticancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity. Our purpose was
Meriem Gaval-Cruz et al.
Molecular interventions, 9(4), 175-187 (2009-09-02)
The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and thereby helps patients reduce alcohol intake. Recent clinical trials, initiated to investigate whether disulfiram could be used to treat individuals
Parvinder Hothi et al.
Oncotarget, 3(10), 1124-1136 (2012-11-21)
Glioblastoma Multiforme (GBM) continues to have a poor patient prognosis despite optimal standard of care. Glioma stem cells (GSCs) have been implicated as the presumed cause of tumor recurrence and resistance to therapy. With this in mind, we screened a
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The Cochrane database of systematic reviews, (1)(1), CD007024-CD007024 (2010-01-22)
Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development. To evaluate the efficacy and the acceptability of disulfiram for cocaine dependence. We searched: PubMed, EMBASE, CINAHL
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