76899

Temozolomide

VETRANAL^®, analytical standard

• Sinonimo/i: 3,4-diidro-3-metil-4-ossoimidazo[5,1-d]-1,2,3,5-tetrazin-8-carbossamide, 3-Metil-4-osso-8-imidazol[5,1-d][1,2,3,5]tetrazina-carbossamide, 4-metil-5-osso-2,3,4,6,8-pentazabiciclo[4.3.0]nona-2,7,9-triene-9-carbossamide, 8-carbamoil-3-metilimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, NSC 362856
• Formula empirica (notazione di Hill): C₆H₆N₆O₂
• Numero CAS: 85622-93-1
• Peso molecolare: 194.15
• Numero MDL: MFCD00866492
• Codice UNSPSC: 41116107
• ID PubChem: 329767423
• NACRES: NA.24

Proprietà

• Grado: analytical standard
• Livello qualitativo: 100
• Nome Commerciale: VETRANAL^®
• Saggio: ≥99.0% (HPLC)
• Durata: limited shelf life, expiry date on the label
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Residuo alla calcinazione: ≤0.2%
• Perdita: ≤0.5% loss on drying
• applicazioni: forensics and toxicology; pharmaceutical (small molecule); veterinary
• Formato: neat
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CN1N=Nc2c(ncn2C1=O)C(N)=O
• InChI: 1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13); BPEGJWRSRHCHSN-UHFFFAOYSA-N

Descrizione

Descrizione generale

Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.

Note legali

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H319,H335,H340,H350,H360FD
• Consigli di prudenza: P201 - P202 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges