63013
α2-Macroglobulin from human plasma
≥90% (GE)
Sinonimo/i:
α2-M
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About This Item
Prodotti consigliati
Origine biologica
human plasma
Livello qualitativo
Saggio
≥90% (GE)
PM
~720 kDa (four glycoprotein subunits)
tecniche
cell culture | mammalian: suitable
Solubilità
H2O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... A2M(2)
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Applicazioni
Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.
Azioni biochim/fisiol
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Risultati analitici
100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0
Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
Altre note
Conformational changes of α2-M
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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P A Roche et al.
Biochemistry, 28(19), 7629-7636 (1989-09-19)
Treatment of the human plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) with proteinase results in conformational changes in the inhibitor and subsequent activation and cleavage of the internal thiolester bonds of alpha 2M. Previous studies from this laboratory have shown
J J Feige et al.
Hormone research, 45(3-5), 227-232 (1996-01-01)
alpha 2-Macroglobulin (alpha 2M) is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M
Paul Dent et al.
Journal of cellular physiology, 235(10), 6862-6874 (2020-01-28)
We have extended our analyses of (curcumin+sildenafil) biology. The drug combination caused vascularization and degradation of mutant K-RAS that correlated with reduced phosphorylation of ERK1/2, AKT T308, mTORC1, mTORC2, ULK1 S757, STAT3, STAT5, and NFκB and increased phosphorylation of eIF2α
Alpha 2-macroglobulin.
H Ishibashi et al.
Methods in enzymology, 163, 485-495 (1988-01-01)
Yonathan Uriel et al.
Insect science, 27(2), 256-265 (2018-07-27)
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