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Key Documents

61347

Supelco

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Sinonimo/i:

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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About This Item

Formula empirica (notazione di Hill):
C15H14N2O2
Numero CAS:
Peso molecolare:
254.28
Beilstein:
1540211
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥99% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
BMPDWHIDQYTSHX-UHFFFAOYSA-N

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Descrizione generale

10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.

Applicazioni

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Environment

Indicazioni di pericolo

Consigli di prudenza

Classi di pericolo

Aquatic Chronic 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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BIA 2-093

Oxcarbazepine European Pharmacopoeia (EP) Reference Standard

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Supelco

PHR1825

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Supelco

PHR1635

Oxcarbazepine

Johannes Pohl et al.
Environmental science & technology, 54(5), 2913-2921 (2020-01-29)
Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional
Anne-Catherine Servais et al.
Journal of chromatography. A, 1467, 306-311 (2016-07-22)
A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its
Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Maia SdBM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
Saracino M A, et al.
Analytica Chimica Acta, 661(2), 222-228 (2010)
Binding of licarbazepine enantiomers to mouse and human plasma proteins.
Fortuna A, et al.
Biopharmaceutics & Drug Disposition, 31(5-6), 362-366 (2010)

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