MABS481

Anti-PL Scramblase 3, clone 3B4 Antibody

clone 3B4, from mouse

• Sinonimo/i: Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• Clone: 3B4, monoclonal
• application: WB
• Reattività contro le specie: human, mouse
• tecniche: western blot: suitable
• citations: 1

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 3B4, monoclonal
• Reattività contro le specie: human, mouse
• tecniche: western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_001161969
• N° accesso UniProt: Q9JIZ9
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PLSCR3(57048)

Descrizione

Descrizione generale

Phospholipid scramblase 3 (PL scramblase 3), also known as Ca(2+)-dependent phospholipid scramblase 3, and encoded by the gene name PLSCR3, is a member of the phospholipid scramblase family. Recent studies have indicated that PL scramblase 3 may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. PL scramblase 3 is suggested to play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. It may also play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. PL scramblase 3 has been demonstrated to interact with PDCD6 in a calcium-dependent manner.

Immunogeno

Recombinant protein corresponding to human PL Scramlase 3.

Applicazioni

This Anti-PL Scramblase 3 antibody is validated for use in Western Blotting for the detection of PL Scramblase 3.

Western Blotting Analysis: A representative lot detected PL Scramlase 3 in SH-SY5Y cell lysate (Chu, C.T., et al. (2013). Nature Cell Biology. 15(10):1197-1205).
Western Blotting Analysis: A representative lot detected PL Scramlase 3 in primary adipocytes lysate (Wiedmer, T., et al. (2004). PNAS. 101(36):13296-13301).

Qualità

Evaluated by Western Blotting in NIH-3T3/L1 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected PL Scramlase 3 in 10 µg of NIH-3T3/L1 cell lysate.

Descrizione del bersaglio

~31 kDa observed

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to lot specific datasheet.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1