MABN624

Anti-Pan-QKI Antibody, clone N147/6

clone N147/6, from mouse

• Sinonimo/i: Protein quaking, Hqk, HqkI, QKI
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: N147/6, monoclonal
• Reattività contro le specie: mouse, rat, human
• tecniche: western blot: suitable
• Isotipo: IgG2bκ
• N° accesso NCBI: NP_006766
• N° accesso UniProt: Q96PU8
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... QKI(9444)

Descrizione

Descrizione generale

QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients.

Specificità

This antibody demonstrates cross reactivity against QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of California, Davis.).

Immunogeno

Recombinant protein corresponding to human Pan-QKI.

Applicazioni

Anti-Pan-QKI Antibody, clone N147/6 is a highly specific mouse monoclonal antibody & that targets QKI & has been tested in western blotting.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pan-QKI in human frontal cortex.

Immunohistochemistry Analysis: A representative lot detected Pan-QKI in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).

Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of rat brain tissue.

Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of mouse brain membrane tissue.

Western Blotting Analysis: A representative lot detected Pan-QKI in RBM cell lysates and in COS cell lysates transfected with QKI-5, QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of Califorina, Davis.).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Qualità

Evaluated by Western Blotting in rat brain membrane tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Pan-QKI in 10 µg of rat brain membrane tissue lysate.

Descrizione del bersaglio

~36-40 kDa observed. Uniprot describes six isoforms observed between 35-38 kDa Uncharacterized band(s) may be observed in some cell lysates.

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Rat brain membrane tissue lysate.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable