MABN371

Anti-KChIP2 potassium channel subunit Antibody, clone 60/73

clone 60/73, from mouse

• Sinonimo/i: Kv channel-interacting protein 2, KChIP2, A-type potassium channel modulatory protein 2, Potassium channel-interacting protein 2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 60/73, monoclonal
• Reattività contro le specie: rat, human, mouse
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_001029133
• N° accesso UniProt: Q9JM59
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... KCNIP2(30819)

Descrizione

Descrizione generale

KCHIP2, also known as Kv channel-interacting protein 2 (KChIP2), or A-type potassium channel modulatory protein 2, or Potassium channel-interacting protein 2, and encoded by the gene Kcnip2/Kchip2, is the regulatory subunit of the Kv4/D Shal-type voltage gated inactivating potassium channel. KCHIP2 modulates the activities of Kv4.2 and Kv4.3 potassium channels. KCHIP2 is localized to the cell membrane but is a peripheral membrane protein. KCHIP2 is expressed in heart, brain and lung. In brain, KCHIP2 is abundantly expressed in striatum, hippocampus, and olfactory bulb, but moderate to low expression is seen in cerebral cortex thalamus and hypothalamus. KCHIP2 has multiple isoforms in the different tissues. Isoform 1 is predominant in cerebral cortex, striatum and hippocampus, and all three isoforms are equally expressed in olfactory bulb, but in heart only isoform 3 predominates.

Specificità

This antibody does not cross react with rat KChIP1 and KChIP3 (Prof. J. Trimmer, University of California, Davis).

Immunogeno

GST-tagged recombinant protein corresponding to rat KChIP2 potassium channel subunit.

Applicazioni

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KChIP2 potassium channel subunit in human cerebral cortex tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-KChIP2 potassium channel subunit Antibody, clone 60/73 is validated for use in western blotting & IHC for the detection of KChIP2 potassium channel subunit.

Qualità

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected KChIP2 potassium channel subunit in 10 µg of mouse brain tissue lysate.

Descrizione del bersaglio

~ 35 kDa observed. Uncharacterized band(s) may appear in some lysates.

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable