MABF271

Anti-FPR1/2 Antibody, clone NFPR1

clone NFPR1, from mouse

• Sinonimo/i: Anti-Formyl Peptide Receptor 1/2, FMLP1/2, fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: NFPR1, monoclonal
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable; immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_001180235
• N° accesso UniProt: P21462
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... FPR1(2357)

Descrizione

Descrizione generale

N-formy peptide receptor 1 (also known as N-formylpeptide chemoattractant receptor or fMet-Leu-Phe receptor) & 2 (also known as RFP, FMLP-R-I, Lipoxin A4 receptor, LXA4 receptor, FMLP-related receptor I, Formyl peptide receptor-like 1) are multi-pass cell membrane G protein-coupled receptors (GPCRs) encoded by the FPR1 (also known as FPR and FMLP) and FPR2 (also known as FPR2 and FMLP-R-II) gene in human, respectively. The FPR1 gene encodes the high-affinity, and FPR2 the low-affinity, receptor for N-formyl-methionyl peptides (FMLP). Both receptors mediate FMLP-induced activation of neutrophils.

Specificità

This antibody is epitope mapped, recognizing cytoplasmic c-terminal tail residues of FPR1 (305-GQDFRERLI-313) and of FPR2 (306- GQDFRERLI-314) (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).

Immunogeno

Epitope: FPR1 (305-GQDFRERLI-313) and FPR2 (306- GQDFRERLI-314)

His-tagged recombinant protein corresponding to the FPR1 (305-GQDFRERLI-313) and FPR2 (306- GQDFRERLI-314) of human FPR1/2.

Applicazioni

Anti-FPR1/2 Antibody, clone NFPR1 is an antibody against FPR1/2 for use in Western Blotting, Flow Cytometry, Immunocytochemistry, Immunoprecipitation.

Flow Cytometry Analysis: A representative lot detected FPR1/2 in human neutraphils (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).
Immunocytochemistry Analysis: A representative lot detected FPR1/2 in human neutraphils (Riesselman, M., et al. (2007). J. Immunol. 179:2520-2531).
Immunoprecipitation Analysis: A representative lot immunoprecipitated FPR1/2 in neutraphils (Maaty, W.S., et al. (2013). JBC. 288(38):27042-27058).
Western Blotting Analysis: A representative lot detected FPR1/2 in neutraphils (Maaty, W.S., et al. (2013). JBC. 288(38):27042-27058).

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Qualità

Evaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected FPR1/2 in 10 µg of THP-1 cell lysate.

Descrizione del bersaglio

~38 kDa observed. Uncharacterized band(s) may appear in some lysates.

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1