MABF172B

Anti-CD4 (human), PerCP, clone SK3 Antibody

clone SK3, from mouse, Peridinin-Chlorophyll-Protein Complex

• Sinonimo/i: T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4, CD4
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: Peridinin-Chlorophyll-Protein Complex
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: SK3, monoclonal
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable
• N° accesso UniProt: P01730
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CD4(920)

Descrizione

Descrizione generale

The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

Immunogeno

Immunogen information for this antibody is proprietary information.

Applicazioni

Anti-CD4 (human), PerCP, clone SK3 Antibody is an antibody against CD4 for use in Flow Cytometry.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Qualità

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg from a representative lot detected CD4 in one million human peripheral blood lymphocytes.

Stato fisico

Purified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.

Purified by size-exclusion chromatography

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg