AB15794
Anti-Dexras1 Antibody
Chemicon®, from rabbit
Sinonimo/i:
Activator of G-Protein Signaling 1, AGS1
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
mouse
Reattività contro le specie (prevista in base all’omologia)
rat (100% immunogen homology), human (100% immunogen homology)
Produttore/marchio commerciale
Chemicon®
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... RASD1(51655)
Descrizione generale
Dexras1 is a member of the superfamily of RAS-g-proteins and directly binds to Gialpha heterotrimeric G-proteins where it appears to promote guanine nucleotide exchange on Gialpha. Dexras1 is implicated in NMDA receptor signaling through nitric oxide synthase.
Specificità
Dexras1 (Activator of G-Protein Signaling 1, AGS1). By Western blot the antibody recognizes a band at ~33 kDa on mouse brain extract. The antibody has also been used to detect Dexras1 in brown adipocyte lysate.
Other species have not been tested
Immunogeno
Synthetic peptide.
Applicazioni
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-Dexras1 Antibody is validated for use in WB for the detection of Dexras1.
Western blot: 1:1,000 on mouse brain extract.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Stato fisico
ImmunoAffinity Purified
Liquid in PBS. Contains no preservative
Stoccaggio e stabilità
6 months at -70°C from date of shipment
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
M J Cismowski et al.
The Journal of biological chemistry, 275(31), 23421-23424 (2000-06-07)
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activator of G-protein signaling), is a human Ras-related G-protein
T E Graham et al.
Endocrinology, 142(6), 2631-2640 (2001-05-18)
Dexras1 is a novel GTP-binding protein that shares structural similarity with the Ras family of small molecular weight GTPases and is strongly and rapidly induced during treatment with dexamethasone. The function of Dexras1 and its contribution to glucocorticoid-dependent signaling in
M J Cismowski et al.
Nature biotechnology, 17(9), 878-883 (1999-09-03)
We describe genetic screens in Saccharomyces cerevisiae designed to identify mammalian nonreceptor modulators of G-protein signaling pathways. Strains lacking a pheromone-responsive G-protein coupled receptor and expressing a mammalian-yeast Galpha hybrid protein were made conditional for growth upon either pheromone pathway
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
McGrath, MF; Ogawa, T; de Bold, AJ
American Journal of Physiology. Heart and Circulatory Physiology null
M Fang et al.
Neuron, 28(1), 183-193 (2000-11-22)
Because nitric oxide (NO) is a highly reactive signaling molecule, chemical inactivation by reaction with oxygen, superoxide, and glutathione competes with specific interactions with target proteins. NO signaling may be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS)
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