8.53074

Boc-Asn(Trt)-OH

Novabiochem^®

• Sinonimo/i: Boc-Asn(Trt)-OH, N-α-t.-Boc-β-trityl-L-asparagine
• Formula empirica (notazione di Hill): C₂₈H₃₀N₂O₅
• Numero CAS: 132388-68-2
• Peso molecolare: 474.55
• Numero MDL: MFCD00153299
• Codice UNSPSC: 12352209
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Nome Commerciale: Novabiochem^®
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Impiego in reazioni chimiche: reaction type: Boc solid-phase peptide synthesis
• Produttore/marchio commerciale: Novabiochem^®
• applicazioni: peptide synthesis
• Gruppo funzionale: amide
• Temperatura di conservazione: 15-25°C
• InChI: 1S/C28H30N2O5/c1-27(2,3)35-26(34)29-23(25(32)33)19-24(31)30-28(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22/h4-18,23H,19H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)/t23-/m0/s1; PYGOCFDOBSXROC-QHCPKHFHSA-N

Descrizione

Descrizione generale

A trityl-protected derivative which increases the solubility of Asn during the coupling step in SPPS ^[1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

^[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.

Linkage

Replaces: 04-12-0187

Risultati analitici

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -21.5 - -16.5 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable