8.00549

Triethylphosphite

for synthesis

• Sinonimo/i: Triethylphosphite
• Formula empirica (notazione di Hill): C₆H₁₅O₃P
• Numero CAS: 122-52-1
• Peso molecolare: 166.16
• Numero MDL: MFCD00009084
• Codice UNSPSC: 12352108
• Numero indice EU: 204-552-5
• NACRES: NA.22

Proprietà

• Tensione di vapore: <6 hPa ( 20 °C)
• Livello qualitativo: 200
• Saggio: ≥97.0% (GC)
• Forma fisica: liquid
• Temp. autoaccensione: 250 °C
• Potenza: 2800 mg/kg LD₅₀, skin (Rabbit)
• Limite di esplosione: 3.75-42.5 % (v/v)
• P. eboll.: 156-158 °C/1013 hPa
• Punto di fusione: -112 °C
• Temp. transizione: flash point 52 °C
• Densità: 0.956 g/cm³ at 20 °C
• Temperatura di conservazione: no temp limit
• InChI: 1S/C6H15O3P/c1-4-7-10(8-5-2)9-6-3/h4-6H2,1-3H3; BDZBKCUKTQZUTL-UHFFFAOYSA-N

Descrizione

Applicazioni

• Mechanism of acylative oxidation-reduction-condensation reactions: Research details the use of triethylphosphite as a stoichiometric reductant in acylative oxidation-reduction-condensation reactions, utilizing benzoisothiazolones as oxidants. This study provides insights into the reaction mechanisms and potential applications in synthetic chemistry (Gangireddy et al., 2017).


• Synthesis and antitumor activity of oxazaphosphinane derivatives: A study on the efficient synthesis of novel oxazaphosphinane derivatives using triethylphosphite, exploring their antitumor activities. The research includes X-ray crystallography, DFT studies, and molecular docking to evaluate the potential medical applications (Bahadi et al., 2023).


• Reductive Ireland-Claisen Rearrangements: Triethylphosphite is highlighted in copper-catalyzed reductive Ireland-Claisen rearrangements of propargylic acrylates and allylic allenoates, demonstrating its role in facilitating complex molecular transformations in organic synthesis (Guo et al., 2022).


• Desulfurization under UV light: Triethylphosphite is used in the synthesis of deoxyglycosides through desulfurization processes under UV light, showcasing its utility in glycoscience and the development of new glycoconjugates for various applications (Ge et al., 2017).


• Detection and identification of volatile trialkylphosphites: A derivatization strategy employing triethylphosphite for the detection and identification of volatile trialkylphosphites using liquid chromatography-online solid phase extraction and offline nuclear magnetic resonance spectroscopy, highlighting its analytical applications (Mazumder et al., 2015).

Risultati analitici

Assay (GC, area%): ≥ 97.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.955 - 0.957
Identity (IR): passes test

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H226 - H302 - H317 - H412
• Consigli di prudenza: P210 - P233 - P273 - P280 - P301 + P312 - P303 + P361 + P353
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 3 - Skin Sens. 1B
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 129.2 °F - closed cup
• Punto d’infiammabilità (°C): 54 °C - closed cup