539211

Protein Methyltransferase Inhibitor, AMI-5

The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinonimo/i: Protein Methyltransferase Inhibitor, AMI-5, Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
• Formula empirica (notazione di Hill): C₂₉H₆Br₄Na₂O₅ · 3H₂O
• Numero CAS: 17372-87-1
• Peso molecolare: 854.00
• Numero MDL: MFCD00005040
• Codice UNSPSC: 12171500
• NACRES: NA.54

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90%
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Colore: red-brown
• Solubilità: water: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [Na+].[Na+].Brc1c2[o][c]3[c](c(c2cc([c]1=O)Br)c4c(cccc4)C(=O)[O-])=CC(=C(C=3Br)[O-])Br
• InChI: 1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2; SEACYXSIPDVVMV-UHFFFAOYSA-L

Descrizione

Descrizione generale

A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC₅₀ against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Altre note

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317,H319
• Consigli di prudenza: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 376.9 °F - Pensky-Martens closed cup
• Punto d’infiammabilità (°C): 191.6 °C - Pensky-Martens closed cup