5.08508

Zonisamide

• Sinonimo/i: Zonisamide, AD 810, CI 912
• Formula empirica (notazione di Hill): C₈H₈N₂O₃S
• Numero CAS: 68291-97-4
• Peso molecolare: 212.23
• Numero MDL: MFCD00865316
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12); UBQNRHZMVUUOMG-UHFFFAOYSA-N

Descrizione

Descrizione generale

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀ = 24.8 µM). Displays neurprotective properties.

A benzisoxazole derivative that acts as an antiepileptic agent and is shown to block voltage-dependent Na(+) channels and T-type Ca(2+) channels. However, it does not serve as anticonvulsant agent in chemically induced seizures in flurothyl and pentetrazole models. Acts as an inhibitor of monoamine oxidase B (MAO-B; IC₅₀ = 24.8 µM). Displays neurprotective properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Azioni biochim/fisiol

Primary Target
Na+ and Ca2+ channels

Attenzione

Toxicity: Harmful (C)

Altre note

Sonsalla, P.K., et al. 2010. Exp. Neurol.221, 329.
Sobieszek, G. et al. 2003. Pol. J. Pharmacol.55, 68.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H302 - H361
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable